1. Start off well rested and well fed! Caffeine is not an answer as it wears off quickly and then you will need more. Your caffeine high can make you jittery and short tempered. This is not the optimum way to start any journey that includes road risks like traffic, weather, etc.
2. Mandatory: Pull over and take breaks every couple of hours and take a walk whether you think you need one or not. Stretch your legs, use the bathroom, splash some cool water on your face, have a snack, do some deep breathing, roll down the windows in your car and replace the air inside your cabin...tired? Take a nap.
3. Got a co-pilot? How about changing drivers for a bit? This is ideal because then each of you can watch the road and each other to make sure the driver is alert. When driving alone, turn on the radio or put on a CD, and keep your window open just an inch. Please don't use your cruise control if you're driving alone at night -- concentrating on your speed can help you stay awake.
4. Park your vehicle off the road if you have to pull over. Never park on the shoulder or in the breakdown lane for any reason unless, of course, it's an emergency.
Gorm Dagoe and